Disruptive agitated behaviors frequently occur in Alzheimer's disease (AD), particularly among nursing home residents. These problem behaviors frequently precipitate nursing home placement and continue to cause patient distress and interfere with necessary care in the nursing home setting. Limited clinical trial data available suggest only modest efficacy and substantial adverse effects for antipsychotic and other psychotropic drugs prescribed for these problems. New approaches to pharmacologic treatment of these problem behaviors would be beneficial. Recent studies suggest increased behavioral sensitivity to central nervous system (CNS) noradrenergic stimulation in AD, and increased CNS noradrenergic outflow in the advanced stages of AD. These CNS noradrenergic characteristics may contribute to the expression of disruptive agitated behaviors in AD. Propranolol is a beta-adrenergic antagonist drug that decreases responsiveness to CNS noradrenergic stimulation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The aim of this study was to examine whether oral propranolol has any effect on neurodevelopment outcomes in young children with problematic infantile hemangiomas (IHs). Thirty-six children with a diagnosis of problematic IH who were treated with oral propranolol were compared with 34 healthy children with no history of propranolol therapy. Patients received propranolol therapy for at least 3 months. Gesell developmental schedules (GDS) were used to evaluate neurodevelopment outcomes in the two groups. The scores of each GDS domain were compared between the two groups. There were no significant differences in developmental quotient (DQ) values for any of the five domains between the patients and healthy controls Infantile hemangioma (IH) is the most common benign tumor in children. Most IHs are small, do not cause any complications, and involute naturally without treatment. However, approximately 10–15% of IHs can lead to compromised function and permanent disfigurement or are life-threatening. In certain cases, timely intervention is crucial for preventing potential sequelae [1, 2].
.pass_color_to_child_links u-margin-left--xs.u-margin-right--sm.u-padding-left--xs.u-padding-right--xs.u-absolute.u-absolute--center.u-width--100.u-flex-align-self--center.u-flex-justify--between.u-serif-font-main--regular.js-wf-loaded .u-serif-font-main--regular.amp-page .u-serif-font-main--regular.u-border-radius--ellipse.u-hover-bg--black-transparent.u-hover-bg--black-transparent:hover. Content Header .feed_item_answer_user.js-wf-loaded . Noreen Kassem is a hospital doctor and a medical writer. Her articles have been featured in "Women's Health," "Nutrition News," "Check Up" and "Alive Magazine." Kassem also covers travel, books, fitness, nutrition, cooking and green living. View Full Profile Beta blockers work by blocking certain sites in the central nervous system called beta-adrenergic receptor sites, as described by Blocking these nerve sites decreases heart rate, blood pressure and anxiety. However, propranolol and other beta blockers can also worsen breathing disorders, such as emphysema and asthma, because they constrict the air passageways of the lungs and can cause fluid build-up in the lungs. This can result in shortness of breath, difficulty breathing and chest tightness in patients who are on propranolol for long periods of time, or who have respiratory disorders. To prevent or decrease this side effect, propranolol is prescribed in divided doses, extended-release capsules, or combined with the diuretic, hydrochlorothiazide, which causes the body to excrete fluids.
If it continues for a long time, the heart and arteries may not function properly. Propranolol oral solution is used to treat proliferating infantile hemangioma. short-term memory loss; shortness of breath; skin irritation or rash, including rash. Hi there. It has been a long time since I have visited this site. After my daughter, Nieve, was diagnosed with a rare segmental hemangioma back in 2010, she.