Antidepressants are commonly used as a treatment option for patients with irritable bowel syndrome with diarrhea (IBS-D). Some antidepressants for IBS have also shown to be effective at low doses in IBS patients with constipation (IBS-C). In addition to the disturbances in intestinal motility (resulting in either diarrhea or constipation) and abdominal pain that are experienced by patients with IBS, recent studies have also shown that the normal function of the brain being able to “turn down” pain signals sent from the gut is impaired. The pain can become severe when the patient is experiencing emotional distress, which may occur due to stresses in life or due to the stress and frustration of IBS symptoms. Antidepressants can help the brain-gut dysfunction of IBS. Tricyclic antidepressants (TCAs) work by affecting the naturally occurring chemical messengers, called neurotransmitters, in the brain and body. TCAs block the absorption (or reuptake) of the neurotransmitters serotonin and norepinephrine. Zoloft (sertraline) belongs to a class of medications called selective serotonin reuptake inhibitors, or SSRIs. These medications work by increasing the level of serotonin in the brain. Low levels of serotonin in the brain are linked to a depressed mood in addition to cognitive difficulties like poor memory. It's important that you don't expect immediate results when taking Zoloft. People typically notice some improvement within a week or two, but it may take several weeks until you feel the full effects of the drug. Also, when you start taking Zoloft, you may experience some side effects. The most common ones include nausea or upset stomach, diarrhea, sweating, tremor, or a decreased appetite.
I have been suffering with constant (although fluctuating) IBS symptoms for almost 2 months now. I have classic symptoms - constant bloating from morning til night but worseing throughout the day, intermittent diarrhoea and constipation, terrible gas, almost constant cramping in my lower abdomen a bit like period pain but relatively mild, lower back pain sometimes and headaches, tiredness etc. It is now having a significant impact on my life and wellbeing. I have probably had IBS for several years but I also have coeliac disease and have been on a complete gluten free diet for about 2 years. I have been taking 50mg sertraline for 7 months now and have had intermittent stomach troubles since starting it (nothing new for me though). However, I started to get horrendous acid indigestion and heart burn in Jan/Feb, about 2 months after starting sertraline. I changed the time of taking my sertraline to the am in March and the heart burn stopped completely. The current problems started at the beginning of April very suddenly and have not stopped since. My GP raised the possibility that sertraline could be the culprit but is reluctant to take me off it. She prescribed mebeverine and peppermint oil 3x a day but it does jack all. Has anybody else had a similar experience with an SSRI antidepressant? As far as scientists know, irritable bowel syndrome doesn't cause depression, and depression doesn’t cause IBS. Sometimes, one condition can make the other one worse. At the same time, treatments that usually relieve the mood disorder can help some people with their IBS symptoms, too. They can give you even more options to consider when you’re looking for relief. The symptoms of irritable bowel syndrome can cause a level of distress that looks like depression. Some people are so worried that their diarrhea, constipation, or other symptoms will flare up that they avoid going to work, school, or out with friends. On the other hand, the mood disorder may influence the way people handle IBS. They may focus less on their social lives and lose interest in activities they once enjoyed. They may feel too tired or hopeless to bother changing their diet to ease digestive symptoms or think they can't treat their constipation or diarrhea well enough. Some depression meds can treat the mood disorder and some of the symptoms of IBS. But they're used in different ways for each condition, so it's important to talk with your doctor to learn how you should take them. Even people with irritable bowel syndrome who aren’t depressed can get relief from antidepressants.
Received Date: August 23, 2017 Accepted Date: September 18, 2017 Published Date: September 22, 2017 Citation: Saleh IM, Mohamed KO, El-Masry M, Kamel NF (2017) Role of Sertraline as a Mono-therapy in Treatment of Irritable Bowel Syndrome and Associated Psychological Problems: A Single-blinded Randomized Controlled Trial. 8 doi: 10.21767/2171-6625.1000218 Background: Irritable bowel syndrome (IBS) is considered one of the most common functional gastrointestinal disorders. The pathogenesis of IBS is still unknown, as it has both physiological and psychological factors. Being a multifactorial disorder, the treatment of IBS is thereby challenging and also conflicting. Conventional therapy might have an effect in mild and recently diagnosed cases but for some while and some extent. So, antidepressant medications were proposed to treat IBS with long lasting effect. This study aimed to compare effect of sertraline to placebo in treatment of IBS and its comorbid anxiety and/or depressive symptoms. Methods: 55 patients were recruited from outpatient clinics at Assiut University Hospitals and were diagnosed as irritable bowel syndrome according to Rome III criteria. Zoloft (sertraline) is a selective serotonin reuptake inhibitor (SSRI) which helps correct the imbalance of serotonin in the brain. Zoloft is commonly prescribed for depression, panic disorder, obsessive-compulsive disorder (OCD), and post-traumatic stress disorder (PTSD). However, it can also be given to IBS patients, usually in lower doses than those given to depressed patients. The most common side effects of Zoloft are constipation, anxiety, dizziness, drowsiness, dry mouth, loss of appetite, nausea, stomach upset and vomiting. I was diagnosed with IBS when I was 18 after three months of horrible tests and dead ends. I was reluctant to accept the diagnosis, but I had spent the last three months in bed with cramps, nausea, diarrhea and constipation and I had become very depressed (although I was in denial about my depression). My doctor prescribed 50mg of Zoloft (half a tablet first, then a full 50mg). I was still hesitant but went with the regimen, and within a month I was back to normal, started college, got engaged, and moved to a new house.
Antidepressants are used as a treatment option for people with IBS-D but. Escitalopram Lexapro; Paroxetine Paxil; Sertraline Zoloft; Fluoxetine Prozac. Hello! I have been suffering with constant although fluctuating IBS symptoms for almost 2 months now. I have classic symptoms - constant bloating from morning til.