How was viagra discovered

Author: ghoul92 Date of post: 23-Feb-2019
<i>Viagra</i> and many other drugs were <i>discovered</i> by chance. Now.

Viagra and many other drugs were discovered by chance. Now.

Over the course of your lifetime you are likely to take more than 14,000 tablets - and that is just the prescription medicines. The average person will have taken one course of antibiotics every two years, and 28,000 painkillers. By the time you are 70 you will probably be taking at least five tablets a day. Although we cannot seem to live without them, how much do we really know about the pills we take? We like to think drugs are designed for exact purposes, but they are often not as targeted as we may hope. The surprising truth is drug design owes more to serendipity than careful design, and their potential may only be discovered when we take them. It turns out that Ventolin inhalers, a treatment for asthma, can also prevent premature labour; and arsenic, a notorious poison, is making a come back as a treatment for leukaemia. The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart.

<b>Viagra</b> History of Discovery <b>How</b> <b>Was</b> Sildenafil Created?

Viagra History of Discovery How Was Sildenafil Created?

Viagra (sildenafil) is one of the most widely-known prescription drug names on the U. ED is a common sexual problem for men and its frequency increases with age. Pfizer realized ED was an unmet medical need and a major opportunity for financial gain. Often dubbed "the little blue pill", Viagra (sildenafil) was the first phosphodiesterase 5 (PDE5) inhibitor approved to treat erectile dysfunction (ED). During the heart clinical trials, researchers discovered that the drug was more effective at inducing erections than treating angina. The sildenafil compound was originally developed by Pfizer for the treatment of hypertension (high blood pressure) and angina pectoris (chest pain due to heart disease). The discovery that sildenafil could lead to an erection was an unplanned event. survey determined about 50 percent of men 40 to 70 years of age experience some degree of ED. In 1998, the FDA approved Viagra, the first oral treatment for erectile dysfunction, under a priority review. At the time of its approval, Viagra had the fastest initial sales growth following its launch of any prescription product, reaching 2008 sales of close to $2 billion. In the late 1980s and 90s, they were looking for a potential treatment for hypertension. Early test results were unremarkable—except for one unusual behavior from the male participants. Michael Reitano, explains, “When the study was over, the patients didn’t want to give back the unused medication.” In another study, Reitano notes the discovery of a curious “side effect” of sildenafil. “One nurse noticed something strange when she went around to check the patients’ blood pressure. That’s when she discovered a prominent side effect of the blood pressure medication—erections. To hide the unexpected erections, the men had turned over.” Before Pfizer shelved as a failed high blood pressure medication, this unexpected side effect quickly became the main feature. Further testing (of a more sexual nature) soon followed. On March 27, 1998, Pfizer received FDA approval to sell the new drug as Viagra, the first oral treatment for erectile dysfunction. And the way we talk about and treat erectile dysfunction—and sexual health—has never been the same.

BBC News - <i>Viagra</i> and other drugs <i>discovered</i> by accident
BBC News - Viagra and other drugs discovered by accident

Jan 20, 2010. Horizon uncovers how drug design owes more to serendipity than careful design and their potential may only be discovered when we take. Prior to the discovery of sildenafil, the active ingredient of Viagra was rather inefficient and borderline pseudo-medicine. Read more of its history.

How was viagra discovered
Rating 4,2 stars - 287 reviews