Azithromycin asthma

Author: [email protected] Date of post: 18-Feb-2019
Weniger <b>Asthma</b>-Exazerbationen durch <b>Azithromycin</b>.

Weniger Asthma-Exazerbationen durch Azithromycin.

It is estimated that over 50 million people around the world suffer from moderate to severe uncontrolled asthma. Chronic airway inflammation and an increased susceptibility to respiratory infections place a high burden on patients who must seek immediate medical attention when experiencing asthma exacerbations or attacks. Although inhaled corticosteroids and bronchodilators are commonly used to manage asthma, they are not enough to prevent exacerbations. For patients with moderate to severe uncontrolled asthma, there is a need for additional treatment. Macrolide antibiotics such as azithromycin have broad antibacterial, antiviral, and anti-inflammatory properties. Previous systematic reviews report that macrolides can alleviate asthma symptoms, but their effect on the rate of exacerbations is not well known. A research team in Australia carried out a randomized clinical trial to determine whether azithromycin can reduce the rate of asthma exacerbations in patients who are currently on inhaled corticosteroid and bronchodilator therapy. More on Asthma on Medical Medical Interview with: Hans Bisgaard, MD, DMSc Professor of Pediatrics The Faculty of Health Sciences University of Copenhagen Head of the Copenhagen Prospective Studies on Asthma in Childhood University of Copenhagen and Naestved Hospital Childhood asthma is often preceded by recurrent asthma-like symptoms in relation to airway infections in the first years of life. Bacteria and viruses are equally associated with the risk of episodes of asthma-like symptoms in these children, suggesting antibiotics as a potential treatment for such episodes. Our study demonstrates a clinically significant shortening of symptom duration by 63% after intervention. The effect size increased with early initiation of treatment, showing a reduction in episode duration of 83% if treatment was initiated before day 6 of the episode. Azithromycin was effective in shortening the episodes even though no pathogenic bacteria was detected. This study is, to our knowledge, the first randomized trial of azithromycin treatment of acute episodes of asthma-like symptoms in young children with a history of recurrent episodes. Azithromycin reduced the duration of episodes of asthma-like symptoms in young children, suggesting that this drug could have a role in acute management of exacerbations.

<i>Azithromycin</i> in treatment of patients with <i>asthma</i> and C. - NCBI

Azithromycin in treatment of patients with asthma and C. - NCBI

Как известно, смертность, морбидность и огромные затраты на лечение при бронхиальной астме (БА) являются результатом острых атак (осложнений) БА. Большинство пациентов с БА имели хотя бы одно обострение на протяжении последнего года. В таких случаях им требуется срочная медицинская помощь. Одной из частых причин обострений являются респираторные вирусные и атипичные бактериальные инфекции. В исследованиях с участием пациентов с обострениями БА определенную эффективность демонстрировали антибиотики. С другой стороны, наряду с уменьшением выраженности симптомов БА они также обладают высокой токсичностью, что снижает их ценность для рутинного назначения при обострениях. Таким образом, вопрос об их применении остается открытым. В новом исследовании, результаты которого опубликованы 19 сентября 2016 г. в журнале «JAMA Internal Medicine», не смогли подтвердить полученные ранее результаты по азитромицину. Commonly reported side effects of azithromycin include: diarrhea, loose stools, and nausea. Other side effects include: abdominal pain, and vomiting. See below for a comprehensive list of adverse effects. Applies to azithromycin: oral powder for suspension, oral powder for suspension extended release, oral tablet Other dosage forms: Along with its needed effects, azithromycin may cause some unwanted effects. Azithromycin Product Information (azithromycin)." Pfizer US Pharmaceuticals, New York, NY. Although not all of these side effects may occur, if they do occur they may need medical attention. Zithromax (azithromycin)." Pfizer US Pharmaceuticals, New York, NY. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Check with your doctor immediately if any of the following side effects occur while taking azithromycin: Some side effects of azithromycin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.

Effect of <b>azithromycin</b> on <b>asthma</b> exacerbations and quality of. - NCBI
Effect of azithromycin on asthma exacerbations and quality of. - NCBI

Lancet. 2017 Aug 12;39010095659-668. doi 10.1016/S0140-67361731281- 3. Epub 2017 Jul 4. Effect of azithromycin on asthma exacerbations and quality. This randomized clinical trial examines whether azithromycin added to standard care for asthma attacks in adults results in clinical benefit.

Azithromycin asthma
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