G&H What are the specific medications most likely to cause pill-induced esophagitis? JWK Antibiotics account for about half of the reported cases. The list of specific antibiotics is very long and is headed by doxycycline. Doxycycline is formulated as a relatively large capsule, which may partially account for its tendency to cause injury. Pill‐induced esophagitis is a complication seen in patients who use certain medications such as tetracycline and non‐steroidal anti‐inflammatory drugs. In this short report, we described five cases of doxycycline‐induced esophagitis with endoscopic images.